PEI Lab @ Zhejiang University
Corresponding/First Author Representative Paper
1. Zhao Y.
2. Shang K, Huang D, Liu J, Yu Z, Bian W, Chen J, Zhao Y, Liu L, Jiang J, Wang Y, Duan Y, Ge J, Zhang S, Zhou C, Han Y, Hu Y, Zheng W, Sun J, Huang H, Pei S#, Qian P#, Sun J#. CD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models. Cell Rep Med. (IF:10.6) 2025 Jun 17;6(6):102148.
3. Pei S*#, Shelton IT, Gillen AE, Stevens BM, Gasparetto M, Wang Y, Liu L, Liu J, Brunetti TM, Engel K, Staggs S, Showers W, Sheth AI, Amaya ML, Minhajuddin M, Winters A, Patel SB, Tolison H, Krug AE, Young TN, Schowinsky J, McMahon CM, Smith CA, Pollyea DA, Jordan CT. A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy. Cancer Discovery (IF:30.6). 2023 Sep 6;13(9):2032-2049.
4. Pei S, Pollyea S, Gustafson A, Stevens B, Minhajuddin M, Fu R, Riemondy K, Gillen A, Sheridan R, Kim J, Costello J, Amaya M, Inguva A, Winters A, Ye H, Krug A, Jones C, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers J, Ashton J, Nemkov T, D’Alessandro A, Gutman J, Fesik S, Ramsey H, Savona M, Smith C, Jordan CT*. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients. Cancer Discovery (IF: 39.4). 2020. Apr;10(4):536-551.
5. Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan A, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT*. AMPK/FIS1-mediated Mitophagy Is Required for Self-renewal of Human AML Stem Cells. Cell Stem Cell (IF: 24.6). 2018 Jul 5;23(1):86-100.
6. Pollyea DA#, Pei S#, Brett S. Jordan CT. The Intriguing Clinical Success of Bcl-2 Inhibition in AML. Annual Review of Cancer Biology. 2021 Mar Vol. 5:277-289.
7. Pei S, Minhajuddin M, D’Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT*. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. The Journal of Biological Chemistry. 2016 Oct 14;291(42):21984-22000.
8. Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O’Dwyer MK, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT*. Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells. The Journal of Biological Chemistry. 2013, 288(47): 33542-58.
9. Nasim S#, Pei S#, Hagen FK, Jordan CT, Crooks PA*. Melampomagnolide B: A New Antileukemic Sesquiterpene. Bioorg Med Chem. 2011, 19(4): 1515-1519.
Co-Author Paper
1. Amaya ML, Inguva A, Pei S, Jones C, Krug A, Ye H, Minhajuddin M, Winters A, Furtek SL, Gamboni F, Stevens B, D'Alessandro A, Pollyea DA, Reigan P, Jordan CT. The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation. Blood. 2022 Jan 27;139(4):584-596.
2. Cherry EM, Abbott D, Amaya M, McMahon C, Schwartz M, Rosser J, Sato A, Schowinsky J, Inguva A, Minhajuddin M, Pei S, Stevens B, Winters A, Jordan CT, Smith C, Gutman JA, Pollyea DA. Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia. Blood Adv. 2021 Dec 28;5(24):5565-5573.
3. Ye H, Minhajuddin M, Krug A, Pei S, Culp-Hill R, Ponder J, Deblooois E, Schniedewind B, Amaya M, Inguva A, Stevens B, Pollyea DA, Christians U, D’Alessandro A, Jordan CT. The Hepatic Microenvironment Uniquely Protects Leukemia Cells Through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discovery. 2020 Oct 7;CD-20-0318.
4. Stevens BM, Jones CL, Pollyea DA, Culp-Hill R, D’Alessandro A, Winters A, Krug A, Abbott D, Goosman M, Pei S, Gillen AE, Savona MR, Smith C, Jordan CT*. Fatty Acid Metabolism Mediates Venetoclax Resistance in Acute Myeloid Leukemia Stem Cells. Nature Cancer. 2020. 1176–1187(2020).
5. Jones CL, Stevens BM, Pollyea DA, Culp-Hill R, Reisz JA, Nemkov T, Gehrke S, Krug A, Winters A, Pei S, Gustafson A, Ye H, Inguva A, Amaya M, Minhajuddin M, Gamboni F, Abbott D, DeGregoori J, Smith C, D’Alessandro A, Jordan CT*. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells. Cell Stem Cell. 2020. Aug. 14.
6. Jones CL, Stevens BM, D’Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, Degregori J, Pollyea DA, Jordan CT*. Cysteine Depletion Targets Leukemia Stem Cells Through Inhibition of Electron Transport Complex II. Blood. 2019 Jul 25;134(4):389-394.
7. Adane B, Ye H, Khan N, Pei S, Minhajuddin M, Stevens BM, Jones CL, D’Alessandro A, Reisz JA, Zaberezhnyy V, Gasparetto M, Ho T, Kelly KK, Myers JR, Ashton JM, Siegenthaler JA, Kume T, Cambell EL, Pollyea DA, Becker MW, Jordan CT*. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells. Cell Reports. 2019 April 2; 238-254.
8. Gasparetto M, Pei S, Minhajuddin M, Stevens B, Smith CA*, Seligman P*. Low Ferroportin Expression in AML is Correlated with Good Risk Cytogenetics, Improved Outcomes and Increased Sensitivity to Chemotherapy. Leukemia Research. 2019 Feb 28; 80:1-10.
9. Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D’Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith CA, Jordan CT*. Venetoclax with Azacitidine Disrupts Energy Metabolism and Targets Leukemia Stem Cells in Acute Myeloid Leukemia Patients. Nature Medicine. 2018. Dec;24(12):1859-1866.
10. Jones CL, Stevens BM, D’Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Reinhold D, Smith CA, Degregori J, Pollyea DA, Jordan CT*. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2018 Nov 12;34(5):724-740.e4.
11. Wang B, Lyu H, Pei S, Song D, Ni J, Liu B*. Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells. Cell Cycle. 2018;17(8):985-996.
12. Gasparetto M, Pei S, Minhajuddin M, Khan N, Pollyea DA, Myers JR, Ashton JM, Becker MW, Vasiliou V, Humphries KR, Jordan CT, Smith CA*. Targeted Therapy for a Subset of Acute Myeloid Leukemias that Lack Expression of Aldehyde Dehydrogenase 1A1. Haematologica. 2017 Jun;102(6):1054-1065.
13. Ye H, Adane B, Khan N, Sullivan T, Minhajuddin M, Gasparetto M, Stevens B, Pei S, Balys M, Ashton JM, Klemm DJ, Woolthuis CM, Stranahan AW, Park CY, Jordan CT*. Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche. Cell Stem Cell. 2016 Jul 7;19(1):23-37.
14. Smith KS, Yadav VK, Pei S, Pollyea DA, Jordan CT, De S*. SomVarIUS: Somatic variant identification from unpaired tissue samples. Bioinformatics. 2016, Mar 15;32(6):808-13.
15. Lim SJ, Scott A, Xiong XP, Vahidpour S, Karijolich J, Guo D, Pei S, Yu YT, Zhou R, and Li WX*. Requirement for CRIF1 in RNA interference and Dicer-2 stability. RNA biology. 2014, 11(9): 1171-9.
16. Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL*. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 2014, 511(7507): 90-3.
17. Lagadinou ED, Sach A, Callahan KP, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, O’Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT*. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell. 2013, 12(3): 329-341.
18. Du J, Cai X, Yao J, Ding X, Wu Q, Pei S, Jiang K, Zhang Y, Wang W, Shi Y, Lai Y, Shen J, Teng M, Huang H, Fei Q, Reddy ES, Zhu J, Jin C, Yao X*. The Mitotic Checkpoint Kinase NEK2A Regulates Kinetochore Microtubule Attachment Stability. Oncogene. 2008, 27(29): 4107-4114.
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